Explanation:

The Protein Atlas is an interactive data visualization tool designed to explore the explained variance and clustering of protein data, complementary to a published research article. This app provides insights into the variance of specific proteins and their clustering patterns, allowing users to interactively analyze protein behavior across different population and factor-based groupings.

Key Features:

1. Explained Variance Tab: Users can select a specific protein to view its top variance contributors, displayed in a horizontal stacked bar chart and a vertical bar chart with error bars, representing the explained variance for each contributing factor.
2. UMAP Plot by Cluster: A visual overview of proteins grouped by clusters, represented by unique colors and labeled with letters, helps users see general clustering patterns of proteins.
3. UMAP Plot by Factor and Population grid: This tab provides a UMAP plot colored by a user-selected factor (e.g., log-transformed or cleaned values) and population set. A gradient color scale visually represents the explained variance for the selected factor across proteins.
4. UMAP Plot by Factor and Population: This tab provides a UMAP plot colored by a user-selected factor (e.g., log-transformed or cleaned values) and population set. A gradient color scale visually represents the explained variance for the selected factor across proteins and the size will change proportionally to the variance explained.

This app enables users to explore protein variance dynamics in detail, supporting protein research and data interpretation and shows PHURI's, Omicscience's & BIH-Charite latest findings.