About this webserver

This webserver provides open access to summary statistics from our work on molecular signatures across 27 incident non-communicable diseases (NCDs) and all-cause mortality for academic purposes.

We used baseline untargeted plasma metabolomics profiling covering 1,014 metabolites using the Metabolon HD4 platform to characterise disease-shared (two-thirds) and disease-specific (one-third) pathways among up to 11,966 participants (219,415 person-years) of the EPIC-Norfolk cohort. We integrated baseline data on over 50 clinical risk factors and traits to put metabolite-disease associations into context.


Cox-proportional hazard models for incident diseases

Exposure: plasma metabolite levels. Outcome: risk of 27 diseases (ICD-10 codes) and all-cause mortality.

Association matrix

Beta estimates and hazard ratios

Summary statistics download

Linear regression models for clinical risk factors

Exposure: >50 baseline characteristics. Outcome: plasma metabolite levels.

Association matrix

Explained variance

Summary statistics download


Any access to summary statistics and other information provided by this webserver is strictly for academic use and not for commercial interest (see Licence terms).
Please contact Dr. Claudia Langenberg for any further information.