Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

Lotta, Pietzner et al. Nature Genetics, 2020 (accepted); preprint available at biorxiv.org
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Chr.: 
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Use GRCh37 coordinates on autosomal chromosomes only. Query size maximum is 200kb.
rs ID: 
+/- bp: 
Retrieve association data up to 100kb up- and downstream of the query SNP.
ENSEMBL gene identifier:
Hint: perform a gene id lookup by entering a gene symbol (e.g., FADS1).
By default, associations with pMA ≤ 0.05 for all metabolites are shown. You can adjust the p-value threshold or select metabolites in the advanced options. To enhance the perfomance of queries over a wide genomic range, select a more restrictive p-value threshold and/or limit the number of metabolites.

p-value threshold (meta-analysis)

Metabolites

Meta-analysis (Z-score-based) Fenland INTERVAL Metabolon INTERVAL NMR KORA TwinsUK Draisma EPIC-Norfolk Kettunen